RENAL PROTECTIVE EFFECT OF GINGER ON WISTAR ALBINO RAT FED WITH DRINKING WATER CONTAINING NITRATE

RENAL PROTECTIVE EFFECT OF GINGER ON WISTAR ALBINO RAT FED WITH DRINKING WATER CONTAINING NITRATE

Abstract

This study aimed to test the renoprotective effect of ginger in rats fed nitrate-treated drinking water. Twenty-one Wistar albino rats were divided into four groups (A, B, C, D). divided into Group A, containing 5 rats, served as a control group. They were fed normal chow and normal drinking water. Group B (consisting of 6 rats) received chow containing 2.4 g of ginger and water treated with 400 mg/l NaNO 3 . Group C (5 rats) was fed normal chow and water treated with 400 mg/l NaNO 3 . Group D (5 rats) was given a chow containing 2.4 g ginger and 2% ascorbic acid and water treated with 400 mg/l NaNO 3 . Renal function tests – urea and creatinine – were performed on blood samples from all four groups. Here are the analysis results:
Urea levels; group A (control) = 4.42 mmol/L; group B (nitrates + ginger) = 6.03 mmol/l, group C (nitrates only) = 5.36 mmol/l, group D (nitrates + ascorbic acid = 6.06 mmol/l) l, creatinine levels, group A (control) = 96 µmol/l) l, group B = 106.33 µmol/l, group C = 105.4 µmol/l, group D = 92.2 µmol/l. Using creatinine, a strong biomarker of renal dysfunction, there was no significant difference between normal control and treatment groups (p > 0.05). Therefore, a nitrate concentration of 400 mg/L administered to rats had no significant adverse effects on rats, and 2% ginger aided normal functioning of the kidneys.