THE BEHAVIORAL TERATOGENIC EFFECT OF CIMETIDINE ON THE OFFSPRINGS OF ALBINO RATS

 

Abstract

PARTICIPATION OF SEX HORMONES
At least a portion of children have the ability to respond sexually, experience sexual pleasure, and have the potential for orgasm during their formative years. It is unknown whether this seemingly variable potential among children is due to varying early learning opportunities, opportunities to realize the potential, or different gentile influences. It has been previously emphasized how crucial gonadal hormones, particularly testosterone, are to structuring early brain growth and function.Gonadal steroid hormones are title in evidence during childhood, but from the ages of 9 or 10 years they start to increase as the child approaches puberty, and from that point on we have to consider the activating role of those hormones on sexuality and the impact they have on sexuality, during three stages of the life course around puberty and during early adolescence, during adulthood until muddle age, and during three stages of the life course around puberty.A normal level of circulating testosterone is necessary for an adult guy to maintain his interest in sex. An otherwise healthy male who takes testicular suppressive medicines to lower his testosterone notices a drop in sexual attraction, which recovers when the procedure is reversed. In the event of testicular dysfunction (primary or secondary hypogonadison). Most males notice a reduction in sexual attraction and ejaculatory ability when testosterone levels fall below the usual range. A testosterone replacement therapy can reverse this. This is a solid, expected result from a sizable number of placebo-controlled studies. Similar trends are seen in nocturnal penile tumescence, or spontaneous erection during sleep, which decreases and returns with testosterone supplementation. It is important to emphasize, however, that normal levels of testosterone are necessary but not sufficient for normal levels of sexual desire. These erections are intriguing manifestations of the brain’s sexual arousability uncomplicated by cognitive processes, and this evidence clearly points to the role of testosterone in the central sexual arousal mechanism. When there are normal levels of testosterone present, these are the factors that can suppress or change sexual desire.There is a normal, though variable, trend for testosterone levels to fall in males after the fifth decade, and this is frequently followed by an age-related decline in sexual interest, making the role of testosterone less evident as men age. Inappropriately, this is sometimes referred to as the “man menopause.” However, there isn’t any concrete proof that testosterone replacement therapy can change this tendency. Along with a decrease in hormone levels, it’s likely that response to testosterone may also reduce (Schiavs, 1999).Additionally, there is a typical (albeit varying) age-related decline in erectile response. As men age, erections become less regular, weaker, and less long-lasting. Although the exact causes are unknown, they may be connected to a shift in the reactivity of neurotransmitters in erectile tissues (Cerner and Chirst, 2000).

THE SIDE EFFECTS OF DRUGS

It is not unexpected that any mechanism is involved in a number of distinct response patterns given the complexity of the brain and its control mechanisms. As a result, the same systems that regulate sexual behavior may also regulate other motivated behaviors like eating or aggression. At this time, it is challenging to create medications that only affect certain areas of brain function. Drugs created for one purpose often have numerous unforeseen or undesirable side effects.Although biochemical mechanisms in the CNS are incredibly complicated, as previously established, we can take into consideration pharmacological effects which are likely to be primarily central and those repdominantly peripheral. Sexual side effects of treatments focused at the as are not rare. Drugs with serotonergic, noradrenergic, and dopaninergic actions may also be taken into account. The most effective examples are moderate antidepressants that block serotonin reuptake (SSRIs like flutxcline; Rosen, Lane, & Menace) (2001). These medications are meant to cure issues with repaid ejaculation. They frequently suppress female organism or cause male ejaculation to decay.

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